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Methotrexate works wonders for my psoriasis. I have been suffering from Psoriasis covering my hands since I remember myself. It is very painful and looks disgusting especially in exacerbation. My palms crack and bleed and people are afraid of communicating with me. In my life I have tried many topicals and other meds but only Methotrexate made me give a sigh of relief. I'm happy to have found it!

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Although this study cannot definitively answer the question regarding the need for re-vaccination after 5 years, it does suggest that the protective effects (at least the antibody response) may be sustained for at least this long in the setting of ongoing treatment with methotrexate.

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Dermatologists have employed the antineoplastic agent methotrexate (MTX, amethopterin) for over 6 decades to treat a variety of skin conditions (Table 1), most prominently psoriasis.

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FDA acceptance of its New Drug Application (NDA) for its lead product candidate, MPI-2505, a subcutaneous injectable methotrexate (MTX) in a ready-to-use injection device, for which the proposed indications are rheumatoid arthritis (RA), poly-articular-course juvenile RA and psoriasis.

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Unlike gold, it cannot be taken less frequently after the first six to 12 months but instead must be continued every week.

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This index incorporates eight items: the number of liquid or very soft stools, abdominal pain, general well-being, extraintestinal manifestations of Crohn's disease, the use of opiates to treat diarrhea, abdominal mass, hematocrit, and body weight; these yield a composite score ranging from 0 to approximately 600.

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