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How long does methotrexate stay in your system after you stop taking it? It takes 5.5 x elimination half-life for a medicine to be totally eliminated. Methotrexate has an elimination half-life of 3 to 10 hours, therefore it will take approximately 55 hours (if we take the maximum time as 10 hours for the half life) which is about 2.3 days for it to be totally out of your system.
Should you take methotrexate on an empty stomach? Oral tablets: Take these by mouth exactly as directed by your doctor; swallow whole with a glass of water on an empty stomach, at least 1 hour before or 2 hours after food or other medications. Avoid taking methotrexate tablets with milk products, since the drug may not work as well.


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